国际眼科纵览

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睑脂成分改变对泪膜表面张力的影响

赖清华 高莹莹   

  1. 362000 福建泉州,福建医科大学附属第二医院眼科
  • 收稿日期:2016-04-21 出版日期:2017-04-22 发布日期:2017-04-20
  • 通讯作者: 高莹莹,Email: gaoyingying1968@163.com
  • 基金资助:

    福建省自然科学基金(2014J01410);福建医科大学教授学术发展基金(JS14030)

Research progress on the surface tension of tear-film influenced by the compositions of meibum

LAI Qing-hua, GAO Ying-ying   

  1. Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University,Quanzhou Fujian, 362000, China
  • Received:2016-04-21 Online:2017-04-22 Published:2017-04-20
  • Contact: GAO Ying-ying,Email: gaoyingying1968@163.com
  • Supported by:

    The Natural Science Foundation of Fujian Province(2141J01410); Professor Academic Development Fund of Fujian Medical University (JS14030)

摘要:

泪膜表面张力是泪膜一个重要的物理性能,它能让泪液均匀地涂布于眼球表面并形成一个稳定的膜性结构。泪膜脂质层主要由睑板腺分泌的脂质构成,睑脂中具有表面活性的脂质成分如磷脂质、游离脂肪酸、o-酰基-ω-羟基脂肪酸等,可在泪膜的非极性脂质层与极性水液层之间形成稳定单分子膜层的两性界面,表面活性分子的性质和活性是维持界面张力的关键因素,降低泪膜表面张力而增加泪膜稳定性,从而延长泪膜破裂时间。(国际眼科纵览, 2017,  41:   125-130)

Abstract:

The surface tension is an important physical property of tear film, which enables the tear fluid to spread over the corneal epithelium and form a stable film. Tear film lipids are mostly composed of meibomian gland lipids (meibum). The surfactants in meibum such as phospolipids, free fatty acid and (o-acyl)-ω-hydroxy fatty acids (OAHFA), can form a monomolecular ampholytic interface. The nature and activity of the surfactant molecules is the key factor which stabilize the tear film by lowering surface tension and increasing tear film break-up time. (Int Rev Ophthalmol,  2017,  41:    125-130)